Chandipura virus: An emerging arboviral threat in india: Epidemiology, pathogenesis, and prospects for prevention

Harshal Arun Kothawade, Prakash Pannalal Muleva *, Gayatri Sadanand Nayak and Unmesh Gulabrao Bhamare

B. Pharm, Department of Pharmacy, GES’s Sir Dr M.S. Gosavi college of pharmaceutical education and research, Maharashtra, India.
 
Research Article
International Journal of Science and Research Archive, 2024, 13(02), 3798-3807.
Article DOI: 10.30574/ijsra.2024.13.2.2607
Publication history: 
Received on 16 November 2024; revised on 24 December 2024; accepted on 27 December 2024
 
Abstract: 
Chandipura Virus (CHPV), belonging to the Rhabdoviridae family, is accountable for a sudden outbreak in rural regions of India. Primarily affecting children, it manifests as an influenza-like illness and neurologic dysfunction. The transmission is facilitated by vectors such as mosquitoes, ticks, and sandflies. The adopted method for diagnosing this virus involves an effective real-time one-step reverse-transcriptase PCR assay. The genome of CHPV is comprised of a negative-sense RNA and encodes five distinct proteins: N, P, M, G, and L. The vital function in the virus's life cycle is carried out by the P protein, whereas the M protein exhibits lethal characteristics. There is currently no specific treatment, and symptomatic relief entails the utilization of mannitol to decrease brain edema. The effectiveness of a Vero cell-based vaccine candidate against CHPV was efficiently evaluated as a preventive measure. Curbing the menace of CHPV involves containing disease-transmitting vectors, ensuring good nutrition, health, hygiene, and fostering awareness in rural areas. Hence, substantial preventive measures need to be implemented to control virus transmission until an effective anti-CHPV agent is developed.
 
Keywords: 
Chandipura Virus (CHPV); Rhabdoviridae; Arbovirus; Neurological Dysfunction; Vaccine Development; Vector Control
 
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