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Evaluation of the cancer stem cell characteristics of acquired resistant BT549 GEM100nM breast cancer cells
Department of Chemical Pathology, Faculty of Basic Clinical Sciences, College of Health Science, Niger Delta University, Bayelsa State, Nigeria.
Research Article
International Journal of Science and Research Archive, 2024, 13(02), 2428–2434.
Article DOI: 10.30574/ijsra.2024.13.2.2442
Publication history:
Received on 28 October 2024; revised on 04 December 2024; accepted on 07 December 2024
Abstract:
Stem cells playing a vital role in cancer biology have drawn more attention in recent years. Many dense cancers, involving the breast, brain, colon, liver, and pancreas, have been found to be associated with cancer stem cells (CSCs). The objective of this research is to evaluate the cancer stem markers of an attained resistant BT549 GEM100nM breast cancer cell line. Fluorescence-activated cell sorting (FASC) results showed that the resistant cell lines contained higher levels of embryonic markers (Nanog, Oct 4, and Sox2) and cancer stem cell markers (ALDH and CD 133) than the parental wild-type cell (BT549). It is thought that these CSC indicators are pivotal for cancer genesis, relapse, spread and treatment resistance.
Keywords:
Cancer stem cells; Resistant cell lines; Stem cell markers; Embryonic cell markers
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Copyright © 2024 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
