Firsthand data acquisition for hypertension, its amelioration by extract of Bougainvillea spectabilis and formulation of nanoparticles

Noman Arif Shaikh 1, *, Mohammed Taufeeque Shaikh 1, Ibaadur Rahmaan Shaikh 2, Nasreen Bano 3, Nitin Sarkate 4, Neeta Paikrao 4, Fouzia Shaikh 1 and Mohammed Akbar Quadri 1

1 Department of Science and Technology, Supreme Global School, Nagsen Colony, Roshan Gate, Aurangabad (MS), India-431001.
2 Department of Homeopathy, Shri Prakash Chand Jain Homeopathic Medical College, Palaskhed, Tal. Jamner, Dist. Jalgaon (MS), India-424206.
3 Department of Science and Technology, Unique Coaching Institute, Aref Colony, Aurangabad (MS), India-431001.
4 Department of Zoology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad (MS), India-431001.
 
Research Article
International Journal of Science and Research Archive, 2024, 13(02), 1864–1872.
Article DOI: 10.30574/ijsra.2024.13.2.2205
Publication history: 
Received on 05 October 2024; revised on 27 November 2024; accepted on 30 November 2024
 
Abstract: 
Hypertension is a widespread cardiovascular condition characterized by persistently elevated blood pressure, leading to serious health complications such as heart disease, stroke, and renal failure. This study investigates the antihypertensive properties of Bougainvillea spectabilis extract, focusing on its potential mechanisms of action and therapeutic efficacy. Using a controlled experimental design, hypertensive rats were treated with varying doses of Bougainvillea spectabilis extract. Blood pressure measurements were taken before and after treatment using a non-invasive tail-cuff method. Phytochemical analysis of the extract revealed a rich composition of bioactive compounds, including flavonoids, alkaloids, and tannins, known for their cardioprotective and vasodilatory effects. Results demonstrated a significant reduction in both systolic and diastolic blood pressure in treated subjects compared to the control group. Additionally, improvements in endothelial function were observed, indicated by increased nitric oxide levels and decreased oxidative stress markers. Histological analysis of vascular tissues showed enhanced integrity and reduced inflammation. These findings suggest that Bougainvillea spectabilis extract exerts a dual action: promoting vasodilation and improving endothelial health. The results support the potential of Bougainvillea spectabilis as a natural antihypertensive agent, highlighting the need for further research to elucidate its mechanisms and evaluate its clinical applicability in managing hypertension.
 
Keywords: 
Hypertension; Bougainvillea spectabilis; Antioxidant; Antioxidant; Phytochemicals; Antimicrobial Activity
 
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