A comprehensive meta-analysis of in vitro studies on polycystic ovary syndrome cell lines

Jayasree V 1, *, Ramya J K 2, Rachana Mol R S 3 and Murugan M 1

1 Department of Organon of Medicine & Centre for Research, Affiliated to The Tamil Nadu Dr. M.G.R Medical University, Chennai, Sarada Krishna Homoeopathic Medical College, Kulasekharam, India.
2 Department of Pathology & Microbiology, Rosy Royal Homoeopathic Medical College & Hospital, Bangalore, India.
3 Department of Research Felicitation centre. Affiliated to The Tamil Nadu Dr. M.G.R Medical University, Chennai, Sarada Krishna Homoeopathic Medical College, Kulasekharam, India.
 
Research Article
International Journal of Science and Research Archive, 2024, 13(01), 1979–1986.
Article DOI: 10.30574/ijsra.2024.13.1.1853
Publication history: 
Received on 22 August 2024; revised on 01 October 2024; accepted on 03 October 2024
 
Abstract: 
Introduction: Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder affecting women of reproductive age. In vitro studies using PCOS cell lines have been instrumental in understanding the pathophysiology and identifying potential therapeutic targets. This meta-analysis aims to synthesize and evaluate the existing literature on PCOS cell line research.
Methods: A systematic search of PubMed, Scopus, and Web of Science databases up to January 2024, using relevant keywords and medical subject headings. Inclusion criteria were original research articles in English, focusing on PCOS cell lines and reporting quantitative data. Data extraction included study design, cell line model, outcomes, and main findings.
Results: A total of 48 studies met the inclusion criteria, involving human granulosa-derived (KGN, COV434), theca-derived (HsTE-1, HsTE-10), and ovarian surface epithelial (IOSE-80) cell lines. These studies focused on the evaluation of hormonal imbalances, insulin resistance, and inflammation. The meta-analysis revealed that PCOS cell lines exhibited increased androgen production, elevated insulin resistance markers, and pro-inflammatory cytokine expression compared to control cell lines.
Conclusion: In vitro studies using PCOS cell lines have provided valuable insights into the molecular mechanisms underlying PCOS pathogenesis. These cell lines serve as valuable tools for understanding the complex interplay between hormonal dysregulation, insulin resistance, and inflammation.
 
Keywords: 
PCOS; Meta-Analysis; KGN; COV434; Hste-1; Hste-10
 
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