Preparation and evaluation of bio-adhesive dosage form of chlorhexidine gluconate

Aditya Sanjay Yewale *, Ajay Ramesh Sapkal, Ganesh Suresh Khandare, Mohit Pravin Zanwar, Nitin Baban Kalaskar, R. H. kale and F. A. Shaikh

PRMSS, Anuradha Collage of pharmacy, Chikhli, Dist. Buldhana, India.
 
Research Article
International Journal of Science and Research Archive, 2024, 13(02), 2837-2850.
Article DOI: 10.30574/ijsra.2024.13.2.2447
Publication history: 
Received on 01 November 2024; revised on 14 December 2024; accepted on 16 December 2024
 
Abstract: 
This research investigates the development and optimization of a novel mucoadhesive buccal film containing chlorhexidine gluconate for enhanced oral health. The introduction highlights the prevalence of oral afflictions and the limitations of conventional oral medications. Mucoadhesive dosage forms are presented as a promising alternative, offering targeted drug delivery and improved therapeutic efficacy. The sections delve into the concept of mucosal dosage forms, explaining their mechanism of action and various applications. The advantages and challenges associated with this delivery system are also discussed.
The methodology outlines the materials and processes involved in formulation the chlorhexidine-loaded the film. The experimental design details the evaluation parameters employed to assess the films quality, including weight uniformity, thickness, surface pH, swelling index, folding endurances, drug content, mucoadhesion, anti-inflammatory activity, moisture loss, in-vitro drug release, anti-microbial activity, and surface morphology using scanning electron microscopy. Overall, this research aims to develop a bio-adhesive buccal film loaded with chlorhexidine gluconate to provide sustained and localizes antimicrobial activity in the oral cavity, potentially improving oral health outcome.
 
Keywords: 
Mucoadhesive; Chlorhexidine; Buccal film; Oral tablets
 
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