Method development and validation of ornidazole by using RP-HPLC

AMALA SADHE *, KRUTHIVENTI. SAI PRIYANKA and AKISHINTALA SREE GAYATRI

Department of Pharmacology, School of Pharmacy, Aditya University, Surampalem, India.
 
Research Article
International Journal of Science and Research Archive, 2024, 13(02), 2015–2022.
Article DOI: 10.30574/ijsra.2024.13.2.2353
Publication history: 
Received on 21 October 2024; revised on 30 November 2024; accepted on 02 December 2024
 
Abstract: 
Analytical way is more suitable, highly precise, safe and selective. Developing analytical method for newly introduced pharmaceutical formulation is a matter of most importance. The technique which is widely used to check the quality of drug is known as ‘CHROMATOGRAPHY’. Our present plan is to develop a new, simple, precise or accurate method for analysis of ORNIDAZOLE formulation after a detailed study a new RP-HPLC method was decided to be developed and validated. Ornidazole is a popular anti-protozoal agent. Different concentrations of drug solutions are prepared for method validation. Injected each level into the chromatographic system and measure the peak area. The accuracy limit is the percentage recovery should be in the range of 98.0% - 102.0%. The total recovery was found to be 100.34% for Ornidazole. The validation of developed method shows that the accuracy is well within the limit, which shows that the method is capable of showing good accuracy and reproducibility.
 
Keywords: 
Ornidazole; RP-HPLC; Accuracy; Validation; Efficacy
 
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