Factors influencing withdrawal of anti-epileptic drugs and management of recurrent seizure: A systematic review

Absar Neyan A 1, Ajans Samuel J 1, Amirtha Varshini M K M 1 and Mohan Kumar M 2, *

1 Doctor of pharmacy, Department of pharmacy practice, Arulmigu Kalasalingam College of Pharmacy, Krishnan Koil, Tamil Nadu
2 Arulmigu Kalasalingam College of Pharmacy, Krishnan Koil, Tamil Nadu, India.
 
Review
International Journal of Science and Research Archive, 2024, 23(03), 419–425.
Article DOI: 10.30574/ijsra.2024.13.1.1658
Publication history: 
Received on 28 July 2024; revised on 06 September 2024; accepted on 09 September 2024
 
Abstract: 
Objective: This study aims to investigate the risk factors associated with seizure recurrence following the withdrawal of antiepileptic drugs (AEDs) in patients with epilepsy. Method: A systemic review of recent literature and clinical studies was conducted, focusing on variables such as patient demographics, epilepsy characteristics, treatment history, comorbid condition, adherence to treatment, withdrawal protocols and seizure outcomes were included. Results: factors like polypharmacy AED drugs, undesirable effects, cognitive impairment, cost, compliance are leads to withdrawal of antiepileptic drugs. which cause recurrence of seizure and severe risk. Only seizure free patient can slowly withdrawal the Anti-epileptic drugs. Management strategies for recurrent seizures post-withdrawal varied, including AED reinitiation, dose adjustment, adjunctive therapies, and epilepsy surgery. Conclusion: Healthcare were optimizing outcomes for epilepsy patients by using gradual tapering strategies, adjunctive therapies, patient education, and diligent follow-up to minimize seizure recurrence and ensure AED withdrawal efficacy.
 
Keywords: 
Anti-epileptic drugs; Seizure recurrence; Cognitive impairment; Cost; Compliance
 
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