Anti-inflammatory potential of green synthesized silver nanoparticles of triphala extract

Aiswarya Lakshmi A.G 1, *, Rakesh Kumar Jat 1 and Siju E.N 2

1 Institute of Pharmaceutical Sciences, Shri Jagdishprasad Jhabramal Tibrewala University, Chudela, Jhunjhunu 333001, Rajasthan, India.
2 Academy of Pharmaceutical Sciences, Kannur, Kerala, India.
 
Research Article
International Journal of Science and Research Archive, 2022, 07(02), 168-172.
Article DOI: 10.30574/ijsra.2022.7.2.0252
Publication history: 
Received on 03 October 2022; revised on 14 November 2022; accepted on 17 November 2022
 
Abstract: 
The present study was to investigate the in vitro anti-inflammatory activity of the hydroalcoholic extract of triphala and its green synthesized silver nanoparticles using the human red blood cells membrane stabilization method and protein denaturation method and the results were compared with standard diclofenac sodium. The presence of flavonoids, phenolics, alkaloids, carbohydrates, and glycosides were found in phytochemical screening. The plant extract and the silver nanoparticles showed positive anti-inflammatory activity through HRBC membrane stabilization and inhibition of protein denaturation in a concentration-dependent manner. The study was concluded that the hydroalcoholic extract and SNPs of triphala exhibited potent anti-inflammatory agent due to the presence of important chemical constituents such as polyphenols and flavonoids and this anti-inflammatory properties help in the prevention of many chronic disorders.
 
Keywords: 
Anti-inflammatory; HRBC membrane stabilization; Protein denaturation; Diclofenac sodium
 
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